Document And Entity Information
Dividend yield
Note To Financial Statement Details Textual
Significant Accounting Policies
Oxford Finance Limited Liability Company [Member]
Represents Oxford finance limited liability company.
Note 2 - Significant Accounting Policies
U.S. federal statutory income tax
Note 3 - Accounts Receivable, Net
Risk-free interest rate
pbyi_AccruedVariableConsiderationCurrent
Accrued variable consideration
Represents current accrued variable consideration.
Note 4 - Prepaid Expenses and Other
pbyi_AccruedClinicalExpensesCurrent
Accrued other clinical development
Represents current accrued clinical expenses.
Note 5 - Property and Equipment
pbyi_AccruedProfessionalFeesLiabilityCurrent
Accrued professional fees
Represents current accrued professional fees liability.
Note 6 - Leases
pbyi_AccruedManufacturingCostsCurrent
Accrued manufacturing costs
Represents current accrued manufacturing costs.
Note 7 - Intangible Assets
Schedule of Deferred Financing Costs [Table Text Block]
Tabular disclosure of deferred financing costs.
Equity Incentive Plan Twenty Eleven [Member]
Represents equity incentive plan 2011.
Note 8 - Accrued Expenses
pbyi_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsInitialContractualTerm
Share-based Compensation Arrangement By Share-based Payment Award, Options Initial Contractual Term (Year)
Represents options initial contractual term for share-based compensation arrangement by share-based payment award.
Note 9 - Debt
Non-vested Stock Options [Member]
Represents non-vested stock options.
Income Tax Disclosure [Text Block]
Note 10 - Stockholders' Equity
Secured Promissory Notes [Member]
Represents secured promissory notes.
Note 12 - Income Taxes
Unrealized gain (loss) on available-for-sale securities, net of tax of $0
Note 2 - Significant Accounting Policies - Segment Information (Details)
Expected volatility
Note 2 - Significant Accounting Policies - Potentially Dilutive Securities Not Included in Calculation of Diluted Net Loss per Share (Details)
Note 2 - Significant Accounting Policies - Assets Measured at Fair Value on Recurring Basis (Details)
us-gaap_AccumulatedAmortizationDeferredFinanceCosts
Less: accumulated amortization
us-gaap_LiabilitiesCurrent
Total current liabilities
Schedule of Maturities of Long-Term Debt [Table Text Block]
Note 2 - Significant Accounting Policies - Summary of Cash Equivalents and Short-term Investment (Details)
Schedule of Debt [Table Text Block]
Note 2 - Significant Accounting Policies - Inventory Balance (Details)
Prepaid Expense and Other Assets [Text Block]
The entire disclosure for prepaid expense and other assets.
Note 3 - Accounts Receivable, Net - Schedule of Accounts Receivable, Net (Details)
Expected life in years (Year)
Other liabilities, current
Note 4 - Prepaid Expenses and Other - Prepaid Expenses and Other (Details)
Note 5 - Property and Equipment - Property and Equipment (Details)
Employee and Nonemployee Stock Option [Member]
Represents employee and nonemployee stock option.
Note 6 - Leases - Future Minimum Lease Payments Under ASC 842 (Details)
Note 6 - Leases - Future Minimum Lease Payments to be Received (Details)
Note 6 - Leases - Supplemental Cash Flow Information Related to Leases (Details)
Note 7 - Intangible Assets - Intangible Assets (Details)
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Note 7 - Intangible Assets - Future Amortization Expense Maturity (Details)
Note 8 - Accrued Expenses - Composition of Current and Long-term Accrued Expenses (Details)
Note 9 - Debt - Schedule of Long Term Debt (Details)
us-gaap_LitigationSettlementAmountAwardedFromOtherParty
Litigation Settlement, Amount Awarded from Other Party
Note 9 - Debt - Schedule of Long Term Debt (Details) (Parentheticals)
Note 9 - Debt - Future Minimum Principal Payments (Details)
Note 9 - Debt - Schedule of Debt Issuance Costs and Discounts (Details)
Share-Based Payment Arrangement, Activity [Table Text Block]
Note 10 - Stockholders' Equity - Options Award Assumptions (Details)
Granted, Weighted Average Grant-Date Fair Value (in dollars per share)
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value (in dollars per share)
Note 10 - Stockholders' Equity - Stock-based Compensation Expense (Details)
Note 10 - Stockholders' Equity - Stock Option Activity (Details)
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue
Vested, Weighted Average Grant-Date Fair Value (in dollars per share)
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
Note 10 - Stockholders' Equity - Restricted Stock Units (Details)
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue
Forfeited, Weighted Average Grant-Date Fair Value (in dollars per share)
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue
Nonvested, Beginning balance, Weighted Average Grant-Date Fair Value (in dollars per share)
Nonvested, Beginning balance, Weighted Average Grant-Date Fair Value (in dollars per share)
Note 12 - Income Taxes - Schedule of Income Before Income Taxes (Details)
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod
Forfeited shares (in shares)
Note 12 - Income Taxes - Schedule of Income Tax Expense (Details)
Note 12 - Income Taxes - Schedule of Income Tax Reconciliation (Details)
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber
Nonvested shares (in shares)
Nonvested shares (in shares)
Note 12 - Income Taxes - Components of Net Deferred Tax Assets (Details)
Note 12 - Income Taxes - Reconciliation of Unrecognized Tax Benefits (Details)
Note 12 - Income Taxes - Cash Taxes Paid (Details)
US Government Agencies Debt Securities [Member]
Notes To Financial Statements
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod
Granted shares (in shares)
Maturity of available-for-sale securities
Notes To Financial Statements [Abstract]
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period (in shares)
Vested shares (in shares)
Vested and expected to vest, weighted average remaining contractual term (Year)
Current portion of long-term debt
Less: current portion
Vested and expected to vest, shares (in shares)
Vested and expected to vest, weighted average exercise price (in dollars per share)
Vested and expected to vest, aggregate intrinsic value
Exercisable, weighted average exercise price (in dollars per share)
Exercisable, weighted average remaining contractual term (Year)
Exercisable, aggregate intrinsic value
Exercisable, shares (in shares)
Outstanding, weighted average remaining contractual term (Year)
Outstanding, aggregate intrinsic value
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value (in dollars per share)
us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt
Purchase of available-for-sale securities
Financial Instruments [Domain]
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
Balance, weighted average exercise price (in dollars per share)
Outstanding, weighted average exercise price (in dollars per share)
Forfeited, weighted average exercise price (in dollars per share)
Expired, weighted average exercise price (in dollars per share)
Financial Instrument [Axis]
Granted, weighted average exercise price (in dollars per share)
Exercised, weighted average exercise price (in dollars per share)
Accrued expenses, current
Total, long-term
us-gaap_EmployeeRelatedLiabilitiesCurrent
Accrued compensation
Lessee, Operating Leases [Text Block]
Accounts payable
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number (in shares)
Balance, shares (in shares)
Balance, shares (in shares)
Retirement Plan Type [Axis]
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod
Expired, shares (in shares)
us-gaap_AccruedBonusesCurrent
Accrued bonus
Retirement Plan Type [Domain]
Property and equipment purchases in accounts payable
us-gaap_OtherAccruedLiabilitiesCurrent
Other
Cash, Cash Equivalent, and Investment [Table Text Block]
us-gaap_PolicyTextBlockAbstract
Accounting Policies
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant (in shares)
us-gaap_AccruedProfessionalFeesCurrent
Accrued legal fees
Forecasted Earnings in Upcoming Year [Member]
Relating to forecasted earnings in upcoming year.
us-gaap_PaymentsToAcquireIntangibleAssets
Purchase of intangible assets
Stock Based Compensation [Member]
Relating to stock based compensation.
us-gaap_AccruedRoyaltiesCurrent
Accrued royalties
us-gaap_PaymentsToAcquirePropertyPlantAndEquipment
Purchase of property and equipment
Medical Affairs [Member]
Relating to medical affairs.
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized (in shares)
Other Research and Development [Member]
Relating to other research and development.
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year)
us-gaap_IncomeTaxesPaidNet
Total income taxes paid (net of refunds)
Current liabilities:
pbyi_IncreaseDecreaseInOperatingLeaseAssetsAndLiabilitiesNet
Increase (Decrease) in Operating Lease Assets and Liabilities, Net
Operating lease assets and liabilities, net
Amount of increase (decrease) in operating lease assets after deduction of operating lease liabilities
Product [Member]
us-gaap_Assets
Total assets
Supplemental disclosure of cash flow information:
us-gaap_OperatingLeaseImpairmentLoss
Operating Lease, Impairment Loss
Plan Name [Axis]
Plan Name [Domain]
Compensation and Employee Benefit Plans [Text Block]
us-gaap_OperatingLeaseExpense
Operating Lease, Expense
us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
us-gaap_SubleaseIncome
Sublease Income
us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition (Year)
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Deferred tax assets
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
us-gaap_PrepaidExpenseAndOtherAssets
Totals
Business Description and Basis of Presentation [Text Block]
Award Type [Domain]
Effective Income Tax Rate Reconciliation [Table]
Net income
Net Income (Loss) Attributable to Parent
Net income
Award Type [Axis]
us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization
Less: accumulated amortization
us-gaap_FiniteLivedIntangibleAssetsNet
Totals
Assets that Continue to be Recognized, Transferred Financial Assets and Other Financial Assets Managed Together [Table]
Restricted Stock Units (RSUs) [Member]
Acquired and in-licensed rights
Share-Based Payment Arrangement, Option [Member]
Warrant [Member]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Antidilutive Securities [Axis]
Antidilutive Securities, Name [Domain]
Commitments and Contingencies Disclosure [Text Block]
us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment
Less: accumulated depreciation
Property and equipment, net
Property and equipment, net
Property, Plant and Equipment, Gross
Long-Term Debt, Type [Axis]
California Franchise Tax Board [Member]
Long-Term Debt, Type [Domain]
pbyi_SubleaseAgreementPotentialMilestonePayments
Sublease Agreement, Potential Milestone Payments
Represents potential milestone payments for sublease agreement.
pbyi_TerminationNoticePeriod
Termination Notice Period (Day)
The termination notice period.
us-gaap_AccountsReceivableGross
Total accounts receivable
Clinical Trial Contracts [Member]
Related to clinical trial contracts.
pbyi_PotentialMilestonePayments
Potential Milestone Payments
The value of potential milestone payments.
Investing activities:
Investments, fair value
pbyi_DebtInstrumentPeriodicPaymentExitPayment
Debt Instrument, Periodic Payment, Exit Payment
Represents the amount of periodic exit fees paid.
Exit payment
Represents the amount of exit fees paid in a period.
us-gaap_ExtinguishmentOfDebtAmount
Less: debt repayment
Accrued legal verdict
Deferred tax assets accrued legal verdict.
Lease liabilities
pbyi_DeferredTaxAssetLeaseLiabilities
Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences from lease liabilities.
us-gaap_DeferredFinanceCostsGross
Debt Issuance Costs, Gross
pbyi_DeferredTaxLiabilitiesAssetsInventory
Inventory
Amount of deferred tax consequences attributable to taxable temporary differences derived from inventory.
us-gaap_IncomeTaxExpenseBenefit
Total
Business credit carryforwards
Deferred tax assets business credit carryforward.
pbyi_IncomeTaxBenefitDueToResearchAndDevelopmentTaxCredits
Income Tax Benefit Due to Research and Development Tax Credits
Income tax benefit due to research and development tax credits.
pbyi_NumberOfMajorCustomers
Number of Major Customers
Represents the number of major customers accounting for 10% or more of the specified concentration risk benchmark, which includes, but not limited to, sales revenue, accounts receivable, etc.
us-gaap_IncreaseDecreaseInAccountsPayable
Accounts payable
pbyi_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsGross
Debt issuance costs and discounts
Amount of gross unamortized debt discount (premium) and debt issuance costs.
The 2011 and 2017 Plans [Member]
Related to the 2011 and 2017 plans.
pbyi_CashCashEquivalentsAndMarketableSecurities
Cash, Cash Equivalents, and Marketable Securities
The value of cash, cash equivalents and marketable securities.
Federal income taxes paid (net of refunds)
Operating costs and expenses
us-gaap_DefinedContributionPlanCostRecognized
Defined Contribution Plan, Cost
State income taxes paid (net of refunds)
us-gaap_RestrictedCash
Restricted Cash
General and administrative
us-gaap_DefinedContributionPlanEmployerMatchingContributionPercent
Defined Contribution Plan, Employer Matching Contribution, Percent of Employees' Gross Pay
Foreign income taxes paid (net of refunds)
Customer 1 [Member]
Represents major customer 1.
Cash and cash equivalents
Royalty [Member]
us-gaap_InterestExpenseNonoperating
Interest expense
Share-based compensation expense
Customer 2 [Member]
Represents major customer 2.
Amendment Flag
us-gaap_ComprehensiveIncomeNetOfTax
Comprehensive income
City Area Code
Maturity date
Use of Estimates, Policy [Policy Text Block]
New Accounting Pronouncements, Policy [Policy Text Block]
Accrued expenses and other
Reclassification, Comparability Adjustment [Policy Text Block]
us-gaap_DebtInstrumentPeriodicPaymentPrincipal
Debt Instrument, Periodic Payment, Principal
us-gaap_GainLossOnSaleOfPropertyPlantEquipment
Loss on disposal of property and equipment
Common stock, shares outstanding (in shares)
Balance (in shares)
Balance (in shares)
Current Fiscal Year End Date
us-gaap_DebtInstrumentBasisSpreadOnVariableRate1
Debt Instrument, Basis Spread on Variable Rate
us-gaap_DebtInstrumentInterestRateStatedPercentage
Debt Instrument, Interest Rate, Stated Percentage
us-gaap_DebtInstrumentInterestRateEffectivePercentage
Debt Instrument, Interest Rate, Effective Percentage
Weighted average discount rate
Document Fiscal Period Focus
Document Fiscal Year Focus
Consolidation, Policy [Policy Text Block]
Document Period End Date
Right-of-use assets obtained in exchange for new operating lease liabilities
Weighted-average remaining lease term (in years) (Year)
Cash equivalents, unrealized gain
Amount, before tax, of unrealized gains on cash and cash equivalents.
Entity File Number
us-gaap_IncreaseDecreaseInPrepaidExpensesOther
Prepaid expenses and other
Entity Emerging Growth Company
us-gaap_DebtInstrumentFaceAmount
Debt Instrument, Face Amount
Document Type
Loss on impairment of asset
Interim Period, Costs Not Allocable [Domain]
Entity Small Business
Entity Shell Company
Document Information [Line Items]
Document Information [Table]
Nature of Expense [Axis]
Entity Public Float
Entity Filer Category
Debt Instrument [Axis]
Entity Current Reporting Status
Debt Instrument, Name [Domain]
Entity Voluntary Filers
Entity Well-known Seasoned Issuer
Variable Rate [Domain]
us-gaap_AccountsReceivableNet
Accounts Receivable, after Allowance for Credit Loss
Total accounts receivable, net
us-gaap_LessorOperatingLeasePaymentsToBeReceived
Total
Award Timing MNPI Disclosure [Text Block]
Schedule of Long-Term Debt Instruments [Table]
Variable Rate [Axis]
us-gaap_ConcentrationRiskPercentage1
Concentration Risk, Percentage
us-gaap_IncreaseDecreaseInAccountsReceivable
Accounts receivable, net
Stock-based compensation
ecd_AwardTmgMnpiCnsdrdFlag
Award Timing MNPI Considered [Flag]
Statement of Comprehensive Income [Abstract]
Entity Tax Identification Number
Entity Central Index Key
Insider Trading Policies and Procedures [Line Items]
us-gaap_LessorOperatingLeasePaymentsToBeReceivedNextTwelveMonths
2026
Depreciation and amortization
Entity Registrant Name
Insider Trading Arrangements [Table]
ecd_InsiderTrdPoliciesProcAdoptedFlag
Insider Trading Policies and Procedures Adopted [Flag]
Entity [Domain]
Customer Concentration Risk [Member]
Legal Entity [Axis]
Lessor, Operating Lease, Payment to be Received, Maturity [Table Text Block]
Entity Address, Address Line One
ecd_NonRule10b51ArrTrmntdFlag
Non-Rule 10b5-1 Arrangement Terminated [Flag]
us-gaap_AmortizationOfIntangibleAssets
Amortization of Intangible Assets
Entity Address, City or Town
ecd_Rule10b51ArrTrmntdFlag
Rule 10b5-1 Arrangement Terminated [Flag]
ecd_Rule10b51ArrAdoptedFlag
Rule 10b5-1 Arrangement Adopted [Flag]
Subsidiary of Common Parent [Member]
Entity Address, Postal Zip Code
Entity Address, State or Province
ecd_NonRule10b51ArrAdoptedFlag
Non-Rule 10b5-1 Arrangement Adopted [Flag]
Concentration Risk Type [Axis]
Material Terms of Trading Arrangement [Text Block]
Concentration Risk Type [Domain]
us-gaap_AllowanceForDoubtfulAccountsReceivable
Allowance for credit losses
Customer 4 [Member]
Represents customer 4.
Entity Common Stock, Shares Outstanding
Trading Arrangements, by Individual [Table]
Customer 3 [Member]
Represents customer 3.
Revenue Benchmark [Member]
us-gaap_IncreaseDecreaseInOtherCurrentAssets
Other current assets
Investments [Domain]
us-gaap_IncreaseDecreaseInInventories
Inventory, net
Trading Symbol
Nature of Operation, Product Information, Concentration of Risk [Table]
Concentration Risk Benchmark [Axis]
Concentration Risk Benchmark [Domain]
Investment Type [Axis]
Shares issued or restricted stock units vested under employee stock plans (in shares)
Local Phone Number
us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period (in shares)
Exercised, shares (in shares)
us-gaap_TableTextBlock
Notes Tables
Shares issued or restricted stock units vested under employee stock plans
us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity
Line of Credit Facility, Maximum Borrowing Capacity
Related and Nonrelated Parties [Axis]
Related and Nonrelated Parties [Domain]
Selling, general and administrative
Provision for credit loss recovery
Accounts Receivable, Credit Loss Expense (Reversal)
Granted, shares (in shares)
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod
Foreited (in shares)
Commercialization
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Secured Overnight Financing Rate (SOFR) Overnight Index Swap Rate [Member]
Raw materials
us-gaap_LiabilitiesAndStockholdersEquity
Total liabilities and stockholders’ equity
Pfizer License Agreement [Member]
Relating to the Pfizer license agreement
Finished goods (materials, labor and overhead)
Work-in-process (materials, labor and overhead)
pbyi_UpfrontLicenseFee
Upfront License Fee
Amount of upfront license fee.
Takeda [Member]
Relating to Takeda.
Accumulated deficit
Accumulated other comprehensive income
Operating costs and expenses:
pbyi_AcquiredInprocessResearchAndDevelopment
Acquired In-process Research and Development
Amount of acquired in-process research and development.
Cash Equivalents [Member]
Research and development
Debt Disclosure [Text Block]
Cash and Cash Equivalents [Axis]
Cash and Cash Equivalents [Domain]
Changes in operating assets and liabilities:
us-gaap_AmortizationOfFinancingCosts
Amortization of Debt Issuance Costs
us-gaap_DisclosureTextBlockAbstract
Notes to Financial Statements
Lease liabilities, long-term
Schedule of Inventory, Current [Table Text Block]
Restricted cash, long-term
Total lease liabilities
Intangible assets, net
Total intangible assets, net
Lease liabilities, current
Lease right-of-use assets, net
us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue
Total minimum lease payments
us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount
Less: imputed interest
Deferred income taxes
Deferred Income Tax Expense (Benefit)
Total deferred
Deferred income tax (expense) benefit
us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearThree
2028
us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFour
2029
us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearFive
2030
us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueAfterYearFive
2031
Fair Value Measurement, Policy [Policy Text Block]
us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo
Finite-Lived Intangible Asset, Expected Amortization, Year Two
Fair Value of Financial Instruments, Policy [Policy Text Block]
us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree
Finite-Lived Intangible Asset, Expected Amortization, Year Three
us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour
Finite-Lived Intangible Asset, Expected Amortization, Year Four
us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths
2026
us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive
Finite-Lived Intangible Asset, Expected Amortization, Year Five
us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueYearTwo
2027
Schedule of Finite-Lived Intangible Assets, Future Amortization Expense [Table Text Block]
Segment Reporting, Policy [Policy Text Block]
us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths
Finite-Lived Intangible Asset, Expected Amortization, Year One
SEC Schedule, 12-09, Valuation Allowances and Reserves [Domain]
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
us-gaap_ShareBasedCompensation
Stock-based compensation
Lessee, Leases [Policy Text Block]
SEC Schedule, 12-09, Valuation Allowances and Reserves Type [Axis]
Earnings Per Share, Policy [Policy Text Block]
Other
us-gaap_PrepaidExpenseOtherNoncurrent
Adjusted Secured Overnight Financing Rate (SOFR) Overnight Index Swap Rate [Member]
The adjusted rate on U.S. dollar, constant-notional interest rate swap that has its variable-rate leg referenced to Secured Overnight Financing Rate (SOFR) with no additional spread over SOFR on variable-rate leg.
Intangible Asset, Finite-Lived [Table]
Income Tax, Policy [Policy Text Block]
us-gaap_AssetsFairValueDisclosure
Totals
Schedule of Finite-Lived Intangible Assets [Table Text Block]
us-gaap_LesseeOperatingLeaseRenewalTerm
Lessee, Operating Lease, Renewal Term (Year)
Research and Development Expense, Policy [Policy Text Block]
us-gaap_Depreciation
Depreciation
Intangible Assets Disclosure [Text Block]
Legal Costs, Policy [Policy Text Block]
Schedule of Cash Taxes Paid [Table Text Block]
Tabular disclosure of cash taxes paid.
Indiana Department of Revenue [Member]
Indiana Department of Revenue
Alabama Department of Revenue [Member]
Alabama Department of Revenue
Reclassified to Non-cash Items [Member]
Reclassified to Non-cash Items
us-gaap_AssetsCurrent
Total current assets
Customer 5 [Member]
Customer 5
Cash equivalents
Section 162(m), percent
Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to Section 162(m) nondeductible expenses.
Share-Based Payment Arrangement [Policy Text Block]
Equity [Text Block]
Investments
Section 162(m)
Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to Section 162(m) nondeductible expenses.
pbyi_DeferredTaxAssetsValuationAllowancePortionReleasedDecreaseInTaxRate
Deferred Tax Assets, Valuation Allowance, Portion Released, Decrease in Tax Rate
The decrease in the effective tax rate as a result of the release of a portion of deferred tax assets valuation allowance.
Pennsylvania Department of Revenue [Member]
Pennsylvania Department of Revenue
Kentucky Department of Revenue [Member]
Kentucky Department of Revenue
South Korean National Tax Service [Member]
South Korean National Tax Service
Common stock - $.0001 par value per share; 100,000,000 shares authorized; 50,408,023 shares issued and outstanding at December 31, 2025 and 49,105,834 issued and outstanding at December 31, 2024
Measurement Frequency [Axis]
Adjustments to reconcile net income to net cash provided by operating activities:
Measurement Frequency [Domain]
Fair Value, Recurring [Member]
Common stock, shares authorized (in shares)
Common Stock, Shares Authorized (in shares)
us-gaap_TangibleAssetImpairmentCharges
Tangible Asset Impairment Charges
Commercial Paper [Member]
Common stock, shares issued (in shares)
us-gaap_LesseeOperatingLeaseDiscountRate
Lessee, Operating Lease, Discount Rate
Common stock, par value (in dollars per share)
Common Stock, Par or Stated Value Per Share (in dollars per share)
us-gaap_ValuationAllowanceDeferredTaxAssetChangeInAmount
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Deferred Tax Asset [Domain]
us-gaap_CommonStockCapitalSharesReservedForFutureIssuance
Common Stock, Capital Shares Reserved for Future Issuance (in shares)
us-gaap_DeferredTaxAssetsValuationAllowance
Deferred Tax Assets, Valuation Allowance
Valuation allowance
Lessee, Lease, Description [Table]
Statistical Measurement [Domain]
Operating cash flows used for operating leases (in thousands)
Maximum [Member]
Supplemental disclosures of non-cash investing and financing activities:
Minimum [Member]
Valuation Allowance by Deferred Tax Asset [Axis]
Product and Service [Axis]
Other assets, current
Product and Service [Domain]
us-gaap_DeferredTaxAssetsNet
Net deferred tax assets
Statistical Measurement [Axis]
Litigation Case [Axis]
Litigation Case [Domain]
us-gaap_DeferredTaxAssetsLiabilitiesNet
Net deferred tax assets (liability)
Prepaid Taxes
Interest paid
us-gaap_OtherPrepaidExpenseCurrent
Other
Prepaid expenses, current
Total, long-term
Income taxes paid
Other deferred tax assets
Geographical [Axis]
Property, Plant and Equipment Disclosure [Text Block]
Geographical [Domain]
us-gaap_DeferredTaxAssetsGross
Deferred Tax Assets, Gross
Gross deferred tax assets
Property, Plant and Equipment [Table Text Block]
Europe [Member]
us-gaap_DeferredIncomeTaxLiabilities
Total deferred tax liabilities
NERLYNX [Member]
Represents NERLYNX.
Inventory
Inventory, Net
Total inventories
CALIFORNIA
us-gaap_PrepaidInsurance
Insurance
us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax
Revenue from Contract with Customer, Including Assessed Tax
Fair Value, Inputs, Level 3 [Member]
Fair Value Hierarchy and NAV [Domain]
Customer [Axis]
Customer [Domain]
Fair Value, Inputs, Level 1 [Member]
Fair Value, Inputs, Level 2 [Member]
Fair Value Hierarchy and NAV [Axis]
Accrued expenses
us-gaap_DeferredTaxAssetsTaxDeferredExpenseReservesAndAccrualsAccruedLiabilities
us-gaap_PropertyPlantAndEquipmentUsefulLife
Property, Plant and Equipment, Useful Life (Year)
Operating activities:
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Revenue [Policy Text Block]
Statement [Line Items]
Allowance for credit loss
Furniture and Fixtures [Member]
Accounts receivable, net of allowance for credit loss of $0 and $362
us-gaap_NumberOfReportableSegments
Number of Reportable Segments
Compensation
Totals, amortized cost
Equity, Capital Unit or Share [Table]
Marketable securities
Additional paid-in capital
AOCI Attributable to Parent [Member]
us-gaap_PrepaidExpenseAndOtherAssetsNoncurrent
Prepaid expenses and other, long-term
Prepaid Expense and Other Assets, Noncurrent
Stockholders’ equity:
Leasehold Improvements [Member]
Property, Plant and Equipment, Policy [Policy Text Block]
Property, Plant and Equipment [Table]
Other income
Long-Lived Tangible Asset [Axis]
us-gaap_NonoperatingIncomeExpense
Total other expenses, net
Long-Lived Tangible Asset [Domain]
Restricted cash, current
Net operating loss carryforwards
Sec 174 R&D expenses
Current assets:
us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations
Cash, cash equivalents and restricted cash, beginning of period
Cash, cash equivalents and restricted cash, end of period
Inventory, Policy [Policy Text Block]
Interest income
us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect
Net (decrease) increase in cash, cash equivalents and restricted cash
us-gaap_Liabilities
Total liabilities
us-gaap_NetCashProvidedByUsedInFinancingActivities
Net cash used in financing activities
Commitments and contingencies (Note 13)
us-gaap_OperatingIncomeLoss
Income from operations
us-gaap_NetCashProvidedByUsedInOperatingActivities
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Net cash provided by operating activities
us-gaap_DeferredTaxLiabilitiesOther
Other deferred tax liabilities
Other income (expenses):
us-gaap_NetCashProvidedByUsedInInvestingActivities
Net cash used in investing activities
Cost of sales
Counterparty Name [Axis]
Counterparty Name [Domain]
Consolidation Items [Domain]
us-gaap_DeferredTaxLiabilitiesLeasingArrangements
Right of use assets
Consolidation Items [Axis]
Marketable Securities, Policy [Policy Text Block]
Takeda License Agreement [Member]
Represents Takeda License Agreement.
Concentration Risk, Credit Risk, Policy [Policy Text Block]
us-gaap_AccruedLiabilitiesCurrentAndNoncurrent
Totals
Liability for Claims and Claims Adjustment Expense [Table]
us-gaap_LettersOfCreditOutstandingAmount
Letters of Credit Outstanding, Amount
us-gaap_PaymentsOfDebtExtinguishmentCosts
Payment of exit costs
Total operating costs and expenses
Total operating costs and expenses
Net proceeds from shares issued under employee stock plans
Retained Earnings [Member]
Total revenue
State
us-gaap_DeferredStateAndLocalIncomeTaxExpenseBenefit
State
Foreign
Additional Paid-in Capital [Member]
Common Stock [Member]
Federal
us-gaap_DeferredFederalIncomeTaxExpenseBenefit
Federal
pbyi_CashAndCashEquivalentsAccumulatedGrossUnrealizedLossBeforeTax
Cash equivalents, unrealized losses
Amount, before tax, of unrealized losses on cash and cash equivalents.
Equity Components [Axis]
Equity Component [Domain]
Athyrium Notes [Member]
Relating to Athyrium Notes.
us-gaap_LongTermDebt
Long-Term Debt
Total
us-gaap_CurrentIncomeTaxExpenseBenefit
Total current
Current income tax (expense)
us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)
us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesForeign
Foreign
us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest
Income Before Income Taxes
New York State Division of Taxation and Finance [Member]
us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)
Domestic
ICFR Auditor Attestation Flag
Other comprehensive income:
State and Local Jurisdiction [Member]
Income Tax Authority, Name [Axis]
us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet
Less: unamortized debt issuance costs and discounts
Included in current portion of debt
Income Tax Authority, Name [Domain]
Income Tax Jurisdiction [Axis]
Income Tax Jurisdiction [Domain]
Domestic Tax Jurisdiction [Member]
Document Annual Report
Computer Equipment [Member]
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
us-gaap_DebtInstrumentUnamortizedDiscount
Debt Instrument, Unamortized Discount, Total
Entity Incorporation, State or Country Code
Total debt, inclusive of $2.0 million exit payment
us-gaap_UnrecognizedTaxBenefits
Unrecognized tax benefits
Unrecognized tax benefits
Accounting Policies [Abstract]
Significant Accounting Policies [Text Block]
us-gaap_OpenTaxYear
Open Tax Year
Document Transition Report
Document Financial Statement Error Correction [Flag]
Selling, General and Administrative Expenses [Member]
Entity Interactive Data Current
Other Nonoperating Income (Expense) [Member]
Security Exchange Name
us-gaap_UnrecognizedTaxBenefitsDecreasesResultingFromPriorPeriodTaxPositions
Gross decreases - tax positions in prior period
us-gaap_UnrecognizedTaxBenefitsIncreasesResultingFromCurrentPeriodTaxPositions
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Title of 12(b) Security
Research and Development Expense [Member]
Statement of Income Location, Balance [Axis]
Statement of Income Location, Balance [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Accounts and Financing Receivables [Table]
Auditor Name
Auditor Firm ID
Auditor Location
us-gaap_ContractualObligation
Contractual Obligation
us-gaap_TaxCreditCarryforwardAmount
Tax Credit Carryforward, Amount
Accrued other liabilities
Research Tax Credit Carryforward [Member]
Anti-dilutive securities not included in calculation of diluted net loss per share (in shares)
Weighted-average shares of common stock outstanding—diluted (in shares)
Tax Credit Carryforward [Axis]
Tax Credit Carryforward, Name [Domain]
us-gaap_OperatingLossCarryforwards
Operating Loss Carryforwards
Statement [Table]
Statement of Financial Position [Abstract]
Net income per share of common stock—diluted (in dollars per share)
Weighted-average shares of common stock outstanding—basic (in shares)
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Other tax adjustments, percent
us-gaap_EffectiveIncomeTaxRateContinuingOperations
Income tax expense, percent
Net income per share of common stock—basic (in dollars per share)
Change in valuation allowance, percent
Statement of Cash Flows [Abstract]
Insurance
Represents the amount of noncurrent prepaid insurance.
Statement of Stockholders' Equity [Abstract]
Income Statement [Abstract]
pbyi_AccruedLiabilitiesNoncurrent
Accrued Liabilities, Noncurrent
Represents noncurrent accrued liabilities.
Post-marketing commitment liability
Represents current post marketing commitment liability.
Customers With More than 10% Accounts Receivable [Member]
Related to customers with more than 10% accounts receivable.
Schedule of Accrued Liabilities [Table Text Block]
2026
us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths
Post-marketing commitment liability, long-term
Represents noncurrent post-marketing commitment liability.
us-gaap_RepaymentsOfDebt
Payment of debt
pbyi_NumberOfSubsidiaries
Number of Subsidiaries
Represents number of subsidiaries.
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
pbyi_DebtInstrumentPeriodicPaymentExitPaymentPercent
Debt Instrument, Periodic Payment, Exit Payment, Percent
The percent exit payment made with periodic payments of debt instrument.
pbyi_PolicyTable
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
pbyi_CashAndCashEquivalentsAndRestrictedCashInExcessOfInsuredLimits
Cash and Cash Equivalents, and Restricted Cash In Excess of Insured Limits
Represents cash and cash equivalents and restricted noncash in excess of insured limits.
Telephone Equipment [Member]
Represents information related to telephone equipment.
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Other nontaxable or nondeductible items, percent
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Post-marketing commitment liability
pbyi_IncreaseDecreaseInPostmarketingCommitmentLiability
Represents increase (decrease) in post-marketing commitment liability.
SBC Options, percent
Accounting Standards Update and Change in Accounting Principle [Table]
us-gaap_EffectiveIncomeTaxRateReconciliationTaxCredits
Tax credits, percent
State and local income taxes, net of federal income tax effect (1), percent
Other Commitments [Table]
Foreign tax effects, percent
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Other tax adjustments
Financing activities:
U.S. federal statutory income tax, percent
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
us-gaap_OtherLiabilitiesNoncurrent
Other liabilities, long-term
Unvested Restricted Stock Units [Member]
Represents information related to unvested restricted stock units.
Prior year adjustment
Change in valuation allowance
Royalties, Policy [Policy Text Block]
Disclosure of accounting policy for realities.
AstraZeneca Litigation [Member]
Judicial proceeding, alternative dispute resolution or claim. For example, but not limited to, name of case, category of litigation, or other differentiating information.
License Fees and Intangible Assets [Policy Text Block]
Disclosure of accounting policy for license fees and intangible assets.
pbyi_MilestonePayment
Milestone Payment
Represents payments for milestone.
Corporate Bond Securities [Member]
pbyi_PercentageOfUnpaidPortionOfMilestonePaymentsInterestRate
Percentage of Unpaid Portion of Milestone Payments Interest Rate
Represents percentage of unpaid portion of milestone payments interest rate.
First 3% of Each Participant's Contributions [Member]
Represents first 3% of each participants' contributions.
Second Two Percent Of Each Participants Contributions [Member]
Represents second two percent of each participants contributions.
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Employment Inducement Incentive Award Plan Twenty Seventeen [Member]
Represents information related to employment inducement incentive award plan 2017.
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Note Purchase Agreement [Member]
Represents information related to note purchase agreement.
pbyi_MilestonePaymentsMaximumAmount
Milestone Payments Maximum Amount
Represents maximum amount of milestone payments.
pbyi_OrdinarySharesOwnershipPercentage
Ordinary Shares Ownership Percentage
Represents percentage of ordinary shares ownership.
Totals, fair value
Represents fair value of cash, cash equivalents and short-term investments.
pbyi_DebtInstrumentExitPaymentPercent
Debt Instrument, Exit Payment Percent
Represents the percentage of principal that makes up an exit payment.
Trade accounts receivable
Represents trade accounts receivable net excluding license revenue receivable.
Prepaid Expense and Other Assets [TableText Block]
Tabular disclosure of prepaid expense and other assets.
Clinical Research [Member]
Represents information related to clinical research.
Accounts Receivable [Text Block]
The entire disclosure for accounts receivable.
Schedule of Accounts Receivable [Table Text Block]
Tabular disclosure of accounts receivable.
us-gaap_StockholdersEquity
Total stockholders’ equity
Balance
Balance
Royalty revenue receivable
Represents information related to royalty revenue receivable.
pbyi_PrepaidCROServicesNoncurrent
CRO services
Represents noncurrent prepaid CRO services.
pbyi_PrepaidOtherClinicalDevelopmentExpenseNoncurrent
Other clinical development
Represents noncurrent prepaid other clinical development expense.
Other nontaxable or nondeductible items
pbyi_AreaOfLeasedProperty
Area of Leased Property (Square Foot)
Represents are of leased property.
Permanent items
CRO services
Represents current prepaid CRO services.
Class of Stock [Axis]
Other clinical development
Represents current prepaid other clinical development.
Total long-term debt, net
Professional fees
Represents current prepaid professional fees.
SBC Options
Lease Agreement Two [Member]
Represents lease agreement two.
Lease Agreement One [Member]
Represents lease agreement one.
Lessee, Operating Leases Related To Supplemental Cash Flow Information [Table Text Block]
Tabular disclosure of operating leases related to supplemental cash flow information for lessee.
pbyi_PercentageOfAnnualRentIncrement
Percentage of Annual Rent Increment
Represents percentage of annual rent increment.
us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
Unrealized losses
pbyi_AreaOfSubleasedProperty
Area of Subleased Property (Square Foot)
Represents area of subleased property.
Unrealized gains
Carryforward of disallowed interest
Reclassification, Type [Domain]
Reclassification, Type [Axis]
pbyi_LeaseOptionToExtendTerm
Lease Option To Extend Term (Year)
Represents lease option to extend term.
Operating Segments [Member]
Investments, amortized cost
pbyi_AccruedDevelopmentCosts
Accrued CRO services
Represents accrued development costs.
us-gaap_IncomeTaxReconciliationTaxCredits
Tax credits
State and local income taxes, net of federal income tax effect (1)
State taxes
Foreign tax effects
Foreign taxes
us-gaap_IncomeTaxReconciliationTaxCreditsResearch
R&D credits