Document And Entity Information
Dividend yield
Note To Financial Statement Details Textual
Significant Accounting Policies
Oxford Finance Limited Liability Company [Member]
Represents Oxford finance limited liability company.
Note 2 - Significant Accounting Policies
Note 3 - Accounts Receivable, Net
Risk-free interest rate
pbyi_AccruedVariableConsiderationCurrent
Accrued variable consideration
Represents current accrued variable consideration.
Note 4 - Prepaid Expenses and Other
pbyi_AccruedClinicalExpensesCurrent
Accrued other clinical development
Represents current accrued clinical expenses.
Note 5 - Leases
pbyi_AccruedProfessionalFeesLiabilityCurrent
Accrued professional fees
Represents current accrued professional fees liability.
Note 6 - Property and Equipment, Net
pbyi_AccruedManufacturingCostsCurrent
Accrued manufacturing costs
Represents current accrued manufacturing costs.
Note 7 - Intangible Assets, Net
Schedule of Deferred Financing Costs [Table Text Block]
Tabular disclosure of deferred financing costs.
Equity Incentive Plan Twenty Eleven [Member]
Represents equity incentive plan 2011.
Note 8 - Accrued Expenses
pbyi_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsInitialContractualTerm
Share-based Compensation Arrangement By Share-based Payment Award, Options Initial Contractual Term (Year)
Represents options initial contractual term for share-based compensation arrangement by share-based payment award.
Note 9 - Debt
Non-vested Stock Options [Member]
Represents non-vested stock options.
Note 10 - Stockholders' Equity
Secured Promissory Notes [Member]
Represents secured promissory notes.
Unrealized loss on available-for-sale securities, net of tax of $0
Note 2 - Significant Accounting Policies - Segment Information (Details)
Note 2 - Significant Accounting Policies - Potentially Dilutive Securities Not Included in Calculation of Diluted Net Loss per Share (Details)
Expected volatility
Note 2 - Significant Accounting Policies - Summary of Reconciliation of Numerators and Denominators of Basic and Diluted Net Income (Loss) Per Share of Common Stock Computations (Details)
Note 2 - Significant Accounting Policies - Assets Measured at Fair Value on Recurring Basis (Details)
us-gaap_AccumulatedAmortizationDeferredFinanceCosts
Less: accumulated amortization
us-gaap_LiabilitiesCurrent
Total current liabilities
Schedule of Maturities of Long-Term Debt [Table Text Block]
Note 2 - Significant Accounting Policies - Summary of Cash Equivalents and Short-term Investment (Details)
Schedule of Debt [Table Text Block]
Note 2 - Significant Accounting Policies - Inventory Balance (Details)
Prepaid Expense and Other Assets [Text Block]
The entire disclosure for prepaid expense and other assets.
Note 3 - Accounts Receivable, Net - Schedule of Accounts Receivable, Net (Details)
Expected life in years (Year)
Other liabilities, current
Note 4 - Prepaid Expenses and Other - Prepaid Expenses and Other (Details)
Note 5 - Leases - Supplemental Cash Flow Information Related to Leases (Details)
Employee and Nonemployee Stock Option [Member]
Represents employee and nonemployee stock option.
Note 5 - Leases - Future Minimum Lease Payments Under ASC 842 (Details)
Note 5 - Leases - Future Minimum Lease Payments to be Received (Details)
Note 6 - Property and Equipment, Net - Property and Equipment, Net (Details)
Note 7 - Intangible Assets, Net - Intangible Assets, Net (Details)
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Note 8 - Accrued Expenses - Composition of Current and Long-term Accrued Expenses (Details)
Note 9 - Debt - Schedule of Long Term Debt (Details)
Note 9 - Debt - Schedule of Long Term Debt (Details) (Parentheticals)
us-gaap_LitigationSettlementAmountAwardedFromOtherParty
Litigation Settlement, Amount Awarded from Other Party
Note 9 - Debt - Future Minimum Principal Payments (Details)
Note 9 - Debt - Schedule of Debt Issuance Costs and Discounts (Details)
Note 10 - Stockholders' Equity - Options Award Assumptions (Details)
Share-Based Payment Arrangement, Activity [Table Text Block]
Note 10 - Stockholders' Equity - Stock-based Compensation Expense (Details)
Note 10 - Stockholders' Equity - Stock Option Activity (Details)
Granted, Weighted Average Grant-Date Fair Value (in dollars per share)
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriodWeightedAverageGrantDateFairValue
Note 10 - Stockholders' Equity - Restricted Stock Units (Details)
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriodWeightedAverageGrantDateFairValue
Vested, Weighted Average Grant-Date Fair Value (in dollars per share)
Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block]
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeituresWeightedAverageGrantDateFairValue
Forfeited, Weighted Average Grant-Date Fair Value (in dollars per share)
Notes To Financial Statements
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedWeightedAverageGrantDateFairValue
Nonvested, Beginning balance, Weighted Average Grant-Date Fair Value (in dollars per share)
Nonvested, Beginning balance, Weighted Average Grant-Date Fair Value (in dollars per share)
Notes To Financial Statements [Abstract]
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsForfeitedInPeriod
Forfeited shares (in shares)
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsNonvestedNumber
Nonvested shares (in shares)
Nonvested shares (in shares)
US Government Agencies Debt Securities [Member]
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsGrantsInPeriod
Granted shares (in shares)
Maturity of available-for-sale securities
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedInPeriod
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period (in shares)
Vested shares (in shares)
Vested and expected to vest, weighted average remaining contractual term (Year)
Current portion of long-term debt
Less: current portion
Vested and expected to vest, shares (in shares)
Vested and expected to vest, weighted average exercise price (in dollars per share)
Vested and expected to vest, aggregate intrinsic value
Exercisable, weighted average exercise price (in dollars per share)
Exercisable, weighted average remaining contractual term (Year)
Exercisable, aggregate intrinsic value
Exercisable, shares (in shares)
Outstanding, weighted average remaining contractual term (Year)
Outstanding, aggregate intrinsic value
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageGrantDateFairValue
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value (in dollars per share)
us-gaap_PaymentsToAcquireAvailableForSaleSecuritiesDebt
Purchase of available-for-sale securities
Financial Instruments [Domain]
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice
Balance, weighted average exercise price (in dollars per share)
Outstanding, weighted average exercise price (in dollars per share)
Forfeited, weighted average exercise price (in dollars per share)
Expired, weighted average exercise price (in dollars per share)
Financial Instrument [Axis]
Granted, weighted average exercise price (in dollars per share)
Exercised, weighted average exercise price (in dollars per share)
Accrued expenses, current
Total, long-term
us-gaap_EmployeeRelatedLiabilitiesCurrent
Accrued compensation
Lessee, Operating Leases [Text Block]
Accounts payable
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number (in shares)
Balance, shares (in shares)
Balance, shares (in shares)
Retirement Plan Type [Axis]
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriod
Expired, shares (in shares)
us-gaap_AccruedBonusesCurrent
Accrued bonus
Retirement Plan Type [Domain]
Property and equipment purchases in accounts payable
us-gaap_OtherAccruedLiabilitiesCurrent
Other
Cash, Cash Equivalent, and Investment [Table Text Block]
us-gaap_PolicyTextBlockAbstract
Accounting Policies
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant (in shares)
us-gaap_AccruedProfessionalFeesCurrent
Accrued legal fees
us-gaap_AccruedRoyaltiesCurrent
Accrued royalties
us-gaap_PaymentsToAcquirePropertyPlantAndEquipment
Purchase of property and equipment
Medical Affairs [Member]
Relating to medical affairs.
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfAdditionalSharesAuthorized
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized (in shares)
Other Research and Development [Member]
Relating to other research and development.
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year)
Current liabilities:
pbyi_IncreaseDecreaseInOperatingLeaseAssetsAndLiabilitiesNet
Operating lease assets and liabilities, net
Amount of increase (decrease) in operating lease assets after deduction of operating lease liabilities
Product [Member]
us-gaap_Assets
Total assets
Supplemental disclosure of cash flow information:
Plan Name [Axis]
Plan Name [Domain]
Compensation and Employee Benefit Plans [Text Block]
us-gaap_OperatingLeaseExpense
Operating Lease, Expense
us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognized
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
us-gaap_SubleaseIncome
Sublease Income
us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition (Year)
Deferred tax assets
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
us-gaap_PrepaidExpenseAndOtherAssets
Totals
Business Description and Basis of Presentation [Text Block]
Award Type [Domain]
Net income (loss)
Net Income (Loss) Attributable to Parent
Net income (loss)
Award Type [Axis]
us-gaap_FiniteLivedIntangibleAssetsAccumulatedAmortization
Less: accumulated amortization
Restricted Stock Units (RSUs) [Member]
Acquired and in-licensed rights
Share-Based Payment Arrangement, Option [Member]
Warrant [Member]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Antidilutive Securities [Axis]
Antidilutive Securities, Name [Domain]
Commitments and Contingencies Disclosure [Text Block]
us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment
Less: accumulated depreciation
Property and equipment, net
Property and equipment, net
Property, Plant and Equipment, Gross
Long-Term Debt, Type [Axis]
Long-Term Debt, Type [Domain]
pbyi_SubleaseAgreementPotentialMilestonePayments
Sublease Agreement, Potential Milestone Payments
Represents potential milestone payments for sublease agreement.
us-gaap_AccountsReceivableGross
Total accounts receivable
pbyi_PotentialMilestonePayments
Potential Milestone Payments
The value of potential milestone payments.
Investing activities:
Investments, fair value
pbyi_DebtInstrumentPeriodicPaymentExitPayment
Debt Instrument, Periodic Payment, Exit Payment
Represents the amount of periodic exit fees paid.
Exit payment
Represents the amount of exit fees paid in a period.
us-gaap_ExtinguishmentOfDebtAmount
Less: debt repayment
us-gaap_DeferredFinanceCostsGross
Debt Issuance Costs, Gross
us-gaap_IncreaseDecreaseInAccountsPayable
Accounts payable
pbyi_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsGross
Debt issuance costs and discounts
Amount of gross unamortized debt discount (premium) and debt issuance costs.
The 2011 and 2017 Plans [Member]
Related to the 2011 and 2017 plans.
pbyi_CashCashEquivalentsAndMarketableSecurities
Cash, Cash Equivalents, and Marketable Securities
The value of cash, cash equivalents and marketable securities.
Unrealized loss on available-for-sale securities, tax
Operating costs and expenses
us-gaap_DefinedContributionPlanCostRecognized
Defined Contribution Plan, Cost
us-gaap_RestrictedCash
Restricted Cash
General and administrative
us-gaap_DefinedContributionPlanEmployerMatchingContributionPercent
Defined Contribution Plan, Employer Matching Contribution, Percent of Employees' Gross Pay
Cash and cash equivalents
Royalty [Member]
us-gaap_InterestExpenseNonoperating
Interest expense
Share-based compensation expense
Amendment Flag
us-gaap_ComprehensiveIncomeNetOfTax
Comprehensive income (loss)
City Area Code
Maturity date
Use of Estimates, Policy [Policy Text Block]
New Accounting Pronouncements, Policy [Policy Text Block]
Accrued expenses and other
us-gaap_DebtInstrumentPeriodicPaymentPrincipal
Debt Instrument, Periodic Payment, Principal
Common stock, shares outstanding (in shares)
Balance (in shares)
Balance (in shares)
Current Fiscal Year End Date
us-gaap_DebtInstrumentBasisSpreadOnVariableRate1
Debt Instrument, Basis Spread on Variable Rate
us-gaap_DebtInstrumentInterestRateStatedPercentage
Debt Instrument, Interest Rate, Stated Percentage
us-gaap_DebtInstrumentInterestRateEffectivePercentage
Debt Instrument, Interest Rate, Effective Percentage
Weighted average discount rate
Document Fiscal Period Focus
Document Fiscal Year Focus
Consolidation, Policy [Policy Text Block]
Document Period End Date
Right-of-use assets obtained in exchange for new operating lease liabilities
Weighted-average remaining lease term (in years) (Year)
Cash equivalents, unrealized gain
Amount, before tax, of unrealized gains on cash and cash equivalents.
Entity File Number
us-gaap_IncreaseDecreaseInPrepaidExpensesOther
Prepaid expenses and other
Entity Emerging Growth Company
us-gaap_DebtInstrumentFaceAmount
Debt Instrument, Face Amount
Document Type
Interim Period, Costs Not Allocable [Domain]
Entity Small Business
Entity Shell Company
Document Information [Line Items]
Document Information [Table]
Nature of Expense [Axis]
Entity Filer Category
Debt Instrument [Axis]
Entity Current Reporting Status
Debt Instrument, Name [Domain]
Variable Rate [Domain]
us-gaap_AccountsReceivableNet
Total accounts receivable, net
us-gaap_LessorOperatingLeasePaymentsToBeReceived
Total
Variable Rate [Axis]
us-gaap_IncreaseDecreaseInAccountsReceivable
Accounts receivable, net
Stock-based compensation
Statement of Comprehensive Income [Abstract]
us-gaap_LessorOperatingLeasePaymentsToBeReceivedRemainderOfFiscalYear
2025
Entity Tax Identification Number
Entity Central Index Key
us-gaap_LessorOperatingLeasePaymentsToBeReceivedNextTwelveMonths
2026
Depreciation and amortization
Entity Registrant Name
Entity [Domain]
Legal Entity [Axis]
Lessor, Operating Lease, Payment to be Received, Maturity [Table Text Block]
Entity Address, Address Line One
us-gaap_AmortizationOfIntangibleAssets
Amortization of Intangible Assets
ecd_NonRule10b51ArrTrmntdFlag
Non-Rule 10b5-1 Arrangement Terminated [Flag]
Entity Address, City or Town
ecd_Rule10b51ArrTrmntdFlag
Rule 10b5-1 Arrangement Terminated [Flag]
Subsidiary of Common Parent [Member]
ecd_Rule10b51ArrAdoptedFlag
Rule 10b5-1 Arrangement Adopted [Flag]
Entity Address, Postal Zip Code
Entity Address, State or Province
ecd_NonRule10b51ArrAdoptedFlag
Non-Rule 10b5-1 Arrangement Adopted [Flag]
Material Terms of Trading Arrangement [Text Block]
us-gaap_AllowanceForDoubtfulAccountsReceivable
Allowance for credit losses
Entity Common Stock, Shares Outstanding
Trading Arrangements, by Individual [Table]
us-gaap_IncreaseDecreaseInOtherCurrentAssets
Other current assets
Investments [Domain]
us-gaap_IncreaseDecreaseInInventories
Inventory, net
Trading Symbol
Investment Type [Axis]
Shares issued or restricted stock units vested under employee stock plans (in shares)
Local Phone Number
us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period (in shares)
Exercised, shares (in shares)
us-gaap_TableTextBlock
Notes Tables
Shares issued or restricted stock units vested under employee stock plans
us-gaap_LineOfCreditFacilityMaximumBorrowingCapacity
Line of Credit Facility, Maximum Borrowing Capacity
Related and Nonrelated Parties [Axis]
Related and Nonrelated Parties [Domain]
Selling, general and administrative
Provision for credit loss recovery
Accounts Receivable, Credit Loss Expense (Reversal)
Granted, shares (in shares)
us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod
Foreited (in shares)
Commercialization
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Secured Overnight Financing Rate (SOFR) Overnight Index Swap Rate [Member]
Raw materials
us-gaap_LiabilitiesAndStockholdersEquity
Total liabilities and stockholders’ equity
Pfizer License Agreement [Member]
Relating to the Pfizer license agreement
Finished goods (materials, labor and overhead)
Work-in-process (materials, labor and overhead)
pbyi_UpfrontLicenseFee
Upfront License Fee
Amount of upfront license fee.
Takeda [Member]
Relating to Takeda.
Accumulated deficit
Accumulated other comprehensive (loss) income
Operating costs and expenses:
pbyi_AcquiredInprocessResearchAndDevelopment
Acquired In-process Research and Development
Amount of acquired in-process research and development.
Cash Equivalents [Member]
Research and development
Debt Disclosure [Text Block]
Cash and Cash Equivalents [Axis]
Cash and Cash Equivalents [Domain]
Changes in operating assets and liabilities:
us-gaap_AmortizationOfFinancingCosts
Amortization of Debt Issuance Costs
us-gaap_DisclosureTextBlockAbstract
Notes to Financial Statements
Subsequent Event [Member]
Lease liabilities, long-term
Schedule of Inventory, Current [Table Text Block]
Restricted cash, long-term
Total lease liabilities
Intangible assets, net
Total intangible assets, net
Subsequent Event Type [Axis]
Lease liabilities, current
Subsequent Event Type [Domain]
Lease right-of-use assets, net
us-gaap_LesseeOperatingLeaseLiabilityPaymentsDue
Lessee, Operating Lease, Liability, to be Paid
Total minimum lease payments
us-gaap_LesseeOperatingLeaseLiabilityUndiscountedExcessAmount
Less: imputed interest
us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseRemainderOfFiscalYear
Finite-Lived Intangible Asset, Expected Amortization, Remainder of Fiscal Year
Fair Value Measurement, Policy [Policy Text Block]
us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearTwo
Finite-Lived Intangible Asset, Expected Amortization, Year Two
Fair Value of Financial Instruments, Policy [Policy Text Block]
us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearThree
Finite-Lived Intangible Asset, Expected Amortization, Year Three
us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFour
Finite-Lived Intangible Asset, Expected Amortization, Year Four
us-gaap_LesseeOperatingLeaseLiabilityPaymentsDueNextTwelveMonths
2026
us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseYearFive
Finite-Lived Intangible Asset, Expected Amortization, Year Five
Segment Reporting, Policy [Policy Text Block]
us-gaap_FiniteLivedIntangibleAssetsAmortizationExpenseNextTwelveMonths
Finite-Lived Intangible Asset, Expected Amortization, Year One
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
us-gaap_ShareBasedCompensation
Stock-based compensation
Lessee, Leases [Policy Text Block]
us-gaap_LesseeOperatingLeaseLiabilityPaymentsRemainderOfFiscalYear
2025
us-gaap_FiniteLivedIntangibleAssetUsefulLife
Finite-Lived Intangible Asset, Useful Life (Year)
Earnings Per Share, Policy [Policy Text Block]
Other
us-gaap_PrepaidExpenseOtherNoncurrent
Adjusted Secured Overnight Financing Rate (SOFR) Overnight Index Swap Rate [Member]
The adjusted rate on U.S. dollar, constant-notional interest rate swap that has its variable-rate leg referenced to Secured Overnight Financing Rate (SOFR) with no additional spread over SOFR on variable-rate leg.
Income Tax, Policy [Policy Text Block]
us-gaap_AssetsFairValueDisclosure
Totals
Schedule of Finite-Lived Intangible Assets [Table Text Block]
Research and Development Expense, Policy [Policy Text Block]
us-gaap_Depreciation
Depreciation
Intangible Assets Disclosure [Text Block]
Legal Costs, Policy [Policy Text Block]
us-gaap_AssetsCurrent
Total current assets
Cash equivalents
Share-Based Payment Arrangement [Policy Text Block]
Equity [Text Block]
Investments
Common stock - $.0001 par value per share; 100,000,000 shares authorized; 49,892,725 shares issued and outstanding at June 30, 2025 and 49,105,834 issued and outstanding at December 31, 2024
Measurement Frequency [Axis]
Adjustments to reconcile net income (loss) to net cash provided by operating activities:
Measurement Frequency [Domain]
Fair Value, Recurring [Member]
Common stock, shares authorized (in shares)
Common Stock, Shares Authorized (in shares)
us-gaap_TangibleAssetImpairmentCharges
Tangible Asset Impairment Charges
Commercial Paper [Member]
Common stock, shares issued (in shares)
us-gaap_LesseeOperatingLeaseDiscountRate
Lessee, Operating Lease, Discount Rate
Common stock, par value (in dollars per share)
Common Stock, Par or Stated Value Per Share (in dollars per share)
us-gaap_CommonStockCapitalSharesReservedForFutureIssuance
Common Stock, Capital Shares Reserved for Future Issuance (in shares)
Statistical Measurement [Domain]
Operating cash flows used for operating leases (in thousands)
Maximum [Member]
Supplemental disclosures of non-cash investing and financing activities:
Other assets, current
Product and Service [Axis]
Product and Service [Domain]
Statistical Measurement [Axis]
Litigation Case [Axis]
Litigation Case [Domain]
Prepaid Taxes
Interest paid
us-gaap_OtherPrepaidExpenseCurrent
Other
Prepaid expenses, current
Total, long-term
Income taxes paid
Geographical [Axis]
Property, Plant and Equipment Disclosure [Text Block]
Geographical [Domain]
Property, Plant and Equipment [Table Text Block]
Europe [Member]
Inventory
Inventory, Net
Total inventories
CALIFORNIA
us-gaap_PrepaidInsurance
Insurance
us-gaap_RevenueFromContractWithCustomerIncludingAssessedTax
Revenue from Contract with Customer, Including Assessed Tax
Fair Value, Inputs, Level 3 [Member]
Fair Value Hierarchy and NAV [Domain]
Fair Value, Inputs, Level 1 [Member]
Fair Value, Inputs, Level 2 [Member]
Fair Value Hierarchy and NAV [Axis]
us-gaap_PropertyPlantAndEquipmentUsefulLife
Property, Plant and Equipment, Useful Life (Year)
Operating activities:
Schedule of Segment Reporting Information, by Segment [Table Text Block]
Revenue [Policy Text Block]
Statement [Line Items]
Allowance for credit loss
us-gaap_NumberOfOperatingSegments
Number of Operating Segments
Furniture and Fixtures [Member]
Accounts receivable, net of allowance for credit loss of $213 and $362
Totals, amortized cost
Marketable securities
Additional paid-in capital
AOCI Attributable to Parent [Member]
us-gaap_PrepaidExpenseAndOtherAssetsNoncurrent
Prepaid expenses and other, long-term
Prepaid Expense and Other Assets, Noncurrent
Stockholders’ equity:
Leasehold Improvements [Member]
Property, Plant and Equipment, Policy [Policy Text Block]
Other income
Long-Lived Tangible Asset [Axis]
us-gaap_NonoperatingIncomeExpense
Total other expenses, net
Long-Lived Tangible Asset [Domain]
Restricted cash, current
Current assets:
us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations
Cash, cash equivalents and restricted cash, beginning of period
Cash, cash equivalents and restricted cash, end of period
Inventory, Policy [Policy Text Block]
Interest income
us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect
Net decrease in cash, cash equivalents and restricted cash
us-gaap_Liabilities
Total liabilities
us-gaap_NetCashProvidedByUsedInFinancingActivities
Net cash used in financing activities
Commitments and contingencies (Note 12)
us-gaap_OperatingIncomeLoss
Income (loss) from operations
us-gaap_NetCashProvidedByUsedInOperatingActivities
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Net cash provided by operating activities
Other income (expenses):
us-gaap_NetCashProvidedByUsedInInvestingActivities
Net cash used in investing activities
Cost of sales
Counterparty Name [Axis]
Counterparty Name [Domain]
Consolidation Items [Domain]
Consolidation Items [Axis]
Marketable Securities, Policy [Policy Text Block]
Concentration Risk, Credit Risk, Policy [Policy Text Block]
us-gaap_AccruedLiabilitiesCurrentAndNoncurrent
Totals
us-gaap_LettersOfCreditOutstandingAmount
Letters of Credit Outstanding, Amount
us-gaap_PaymentsOfDebtExtinguishmentCosts
Payment of exit costs
Total operating costs and expenses
Total operating costs and expenses
Net proceeds from shares issued under employee stock plans
Retained Earnings [Member]
Total revenue
Additional Paid-in Capital [Member]
Common Stock [Member]
pbyi_CashAndCashEquivalentsAccumulatedGrossUnrealizedLossBeforeTax
Cash equivalents, unrealized losses
Amount, before tax, of unrealized losses on cash and cash equivalents.
Equity Components [Axis]
Equity Component [Domain]
Athyrium Notes [Member]
Relating to Athyrium Notes.
us-gaap_LongTermDebt
Long-Term Debt
Total
us-gaap_CurrentIncomeTaxExpenseBenefit
Income tax expense
us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)
us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest
Net income (loss) before income taxes
us-gaap_ClassOfWarrantOrRightNumberOfSecuritiesCalledByWarrantsOrRights
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)
Other comprehensive income (loss):
us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet
Less: unamortized debt issuance costs and discounts
Included in long-term debt
Computer Equipment [Member]
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
us-gaap_DebtInstrumentUnamortizedDiscount
Debt Instrument, Unamortized Discount, Total
Document Quarterly Report
Entity Incorporation, State or Country Code
Total debt, inclusive of $2.0 million exit payment
Accounting Policies [Abstract]
Significant Accounting Policies [Text Block]
Document Transition Report
Selling, General and Administrative Expenses [Member]
Entity Interactive Data Current
Other Nonoperating Income (Expense) [Member]
Security Exchange Name
Title of 12(b) Security
Research and Development Expense [Member]
Statement of Income Location, Balance [Axis]
Statement of Income Location, Balance [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Net effect of dilutive common stock equivalents (in shares)
Accrued other liabilities
Anti-dilutive securities not included in calculation of diluted net loss per share (in shares)
Weighted-average shares of common stock outstanding—diluted (in shares)
Weighted average common stock outstanding for diluted net income (loss) per share (in shares)
Statement [Table]
Statement of Financial Position [Abstract]
Diluted (in dollars per share)
Net income (loss) per share of common stock—diluted (in dollars per share)
Weighted average common stock outstanding for basic net income (loss) per share (in shares)
Weighted-average shares of common stock outstanding—basic (in shares)
Accounts Payable and Accrued Liabilities Disclosure [Text Block]
Basic (in dollars per share)
Net income (loss) per share of common stock—basic (in dollars per share)
us-gaap_PrepaymentFeesOnAdvancesNet
Prepayment Fees on Advances, Net
Statement of Cash Flows [Abstract]
Insurance
Represents the amount of noncurrent prepaid insurance.
2025
us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear
Statement of Stockholders' Equity [Abstract]
Income Statement [Abstract]
pbyi_AccruedLiabilitiesNoncurrent
Accrued Liabilities, Noncurrent
Represents noncurrent accrued liabilities.
Post-marketing commitment liability
Represents current post marketing commitment liability.
Schedule of Accrued Liabilities [Table Text Block]
2026
us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths
Post-marketing commitment liability, long-term
Represents noncurrent post-marketing commitment liability.
us-gaap_RepaymentsOfDebt
Payment of debt
pbyi_NumberOfSubsidiaries
Number of Subsidiaries
Represents number of subsidiaries.
pbyi_DebtInstrumentPeriodicPaymentExitPaymentPercent
Debt Instrument, Periodic Payment, Exit Payment, Percent
The percent exit payment made with periodic payments of debt instrument.
pbyi_CashAndCashEquivalentsAndRestrictedCashInExcessOfInsuredLimits
Cash and Cash Equivalents, and Restricted Cash In Excess of Insured Limits
Represents cash and cash equivalents and restricted noncash in excess of insured limits.
Telephone Equipment [Member]
Represents information related to telephone equipment.
Post-marketing commitment liability
pbyi_IncreaseDecreaseInPostmarketingCommitmentLiability
Represents increase (decrease) in post-marketing commitment liability.
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Financing activities:
us-gaap_OtherLiabilitiesNoncurrent
Other liabilities, long-term
Unvested Restricted Stock Units [Member]
Represents information related to unvested restricted stock units.
AstraZeneca Litigation [Member]
Judicial proceeding, alternative dispute resolution or claim. For example, but not limited to, name of case, category of litigation, or other differentiating information.
License Fees and Intangible Assets [Policy Text Block]
Disclosure of accounting policy for license fees and intangible assets.
pbyi_MilestonePayment
Milestone Payment
Represents payments for milestone.
Corporate Bond Securities [Member]
pbyi_PercentageOfUnpaidPortionOfMilestonePaymentsInterestRate
Percentage of Unpaid Portion of Milestone Payments Interest Rate
Represents percentage of unpaid portion of milestone payments interest rate.
First 3% of Each Participant's Contributions [Member]
Represents first 3% of each participants' contributions.
Second Two Percent Of Each Participants Contributions [Member]
Represents second two percent of each participants contributions.
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Employment Inducement Incentive Award Plan Twenty Seventeen [Member]
Represents information related to employment inducement incentive award plan 2017.
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Note Purchase Agreement [Member]
Represents information related to note purchase agreement.
pbyi_MilestonePaymentsMaximumAmount
Milestone Payments Maximum Amount
Represents maximum amount of milestone payments.
pbyi_OrdinarySharesOwnershipPercentage
Ordinary Shares Ownership Percentage
Represents percentage of ordinary shares ownership.
Totals, fair value
Represents fair value of cash, cash equivalents and short-term investments.
pbyi_DebtInstrumentExitPaymentPercent
Debt Instrument, Exit Payment Percent
Represents the percentage of principal that makes up an exit payment.
Trade accounts receivable
Represents trade accounts receivable net excluding license revenue receivable.
Prepaid Expense and Other Assets [TableText Block]
Tabular disclosure of prepaid expense and other assets.
Clinical Research [Member]
Represents information related to clinical research.
Accounts Receivable [Text Block]
The entire disclosure for accounts receivable.
Schedule of Accounts Receivable [Table Text Block]
Tabular disclosure of accounts receivable.
us-gaap_StockholdersEquity
Total stockholders’ equity
Balance
Balance
Royalty revenue receivable
Represents information related to royalty revenue receivable.
pbyi_PrepaidCROServicesNoncurrent
CRO services
Represents noncurrent prepaid CRO services.
pbyi_PrepaidOtherClinicalDevelopmentExpenseNoncurrent
Other clinical development
Represents noncurrent prepaid other clinical development expense.
pbyi_AreaOfLeasedProperty
Area of Leased Property (Square Foot)
Represents are of leased property.
CRO services
Represents current prepaid CRO services.
Class of Stock [Axis]
Other clinical development
Represents current prepaid other clinical development.
Total long-term debt, net
Professional fees
Represents current prepaid professional fees.
Lease Agreement Two [Member]
Represents lease agreement two.
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Lease Agreement One [Member]
Represents lease agreement one.
Lessee, Operating Leases Related To Supplemental Cash Flow Information [Table Text Block]
Tabular disclosure of operating leases related to supplemental cash flow information for lessee.
pbyi_PercentageOfAnnualRentIncrement
Percentage of Annual Rent Increment
Represents percentage of annual rent increment.
us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax
Unrealized losses
pbyi_AreaOfSubleasedProperty
Area of Subleased Property (Square Foot)
Represents area of subleased property.
Unrealized gains
pbyi_LeaseOptionToExtendTerm
Lease Option To Extend Term (Year)
Represents lease option to extend term.
Operating Segments [Member]
Investments, amortized cost
pbyi_AccruedDevelopmentCosts
Accrued CRO services
Represents accrued development costs.